reprinted from 1) http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2809%2961... 2) http://www.medicalnewstoday.com/articles/195159.php The Lancet, Early Online Publication, 19 July 2010 doi:10.1016/S0140-6736(09)61874-2
The Lancet,
Volume 376, Issue 9737, Page 267, 24 July 2010
doi:10.1016/S0140-6736(09)61874-2
Cite or Link Using DOI
Published Online: 19 July 2010
Vitamin A deficiency in New York City
A 24-year-old, 26 weeks pregnant woman from New York City presented with a 7-week history of progressive loss of vision, most notable at night. Numerous Bitot spots (
figure A) and keratitis (
figure B) were seen on examination of her eyes; however, her retina was grossly normal (
figure C, D). Electroretinography showed a generalised rod-cone dysfunction, and fundus autofluorescence showed faint retinal vasculature in her right eye (
figure E) and a black image in the left eye. Autofluorescence from the left eye of an age-match control is shown (
figure F). Acquired vitamin A deficiency was confirmed by a serum concentration of <0·002 μmol/L (normal range 0·70—2·8 μmol/L). Her vision and the appearance of her anterior segment returned to normal with vitamin A supplementation. Vitamin A deficiency can be secondary to poor intestinal absorption due to bariatric surgery, Crohn's disease or pancreatic dysfunction. Our patient had anorexia nervosa and had limited her diet to white onions, white potatoes, and red meat for the past 7 years. A steal effect from her fetus could have also contributed to her symptoms.
a Edward S. Harkness Eye Institute, Columbia University, New York, NY, USA
b Bernard and Shirlee Brown Glaucoma Laboratory, Department of Pathology & Cell Biology, Columbia University, New York, NY, USA
c Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan
Correspondence to: Dr Stephen H Tsang, Edward Harkness Eye Institute, 160 Fort Washington Ave, Research Annex, Room 513, New York, NY 10032
Source: The Lancet